Spectral Efficiency and Energy Efficiency Tradeoff in Massive MIMO Downlink Transmission with Statistical CSIT

As a key technology for future wireless networks, massive multiple-input multiple-output (MIMO) can significantly improve the energy efficiency (EE) and spectral efficiency (SE), and the performance is highly dependant on the degree of the available channel state information (CSI). While most existing works on massive MIMO focused on the case where the instantaneous CSI at the transmitter (CSIT) is available, it is usually not an easy task to obtain precise instantaneous CSIT. In this paper, we investigate EE-SE tradeoff in single-cell massive MIMO downlink transmission with statistical CSIT. To this end, we aim to optimize the system resource efficiency (RE), which is capable of striking an EE-SE balance. We first figure out a closed-form solution for the eigenvectors of the optimal transmit covariance matrices of different user terminals, which indicates that beam domain is in favor of performing RE optimal transmission in massive MIMO downlink. Based on this insight, the RE optimization precoding design is reduced to a real-valued power allocation problem. Exploiting the techniques of sequential optimization and random matrix theory, we further propose a low-complexity suboptimal two-layer water-filling-structured power allocation algorithm. Numerical results illustrate the effectiveness and near-optimal performance of the proposed statistical CSI aided RE optimization approach.Comment: Typos corrected. 14 pages, 7 figures. Accepted for publication on IEEE Transactions on Signal Processing. arXiv admin note: text overlap with arXiv:2002.0488

LiDAR-Based Place Recognition For Autonomous Driving: A Survey

LiDAR-based place recognition (LPR) plays a pivotal role in autonomous driving, which assists Simultaneous Localization and Mapping (SLAM) systems in reducing accumulated errors and achieving reliable localization. However, existing reviews predominantly concentrate on visual place recognition (VPR) methods. Despite the recent remarkable progress in LPR, to the best of our knowledge, there is no dedicated systematic review in this area. This paper bridges the gap by providing a comprehensive review of place recognition methods employing LiDAR sensors, thus facilitating and encouraging further research. We commence by delving into the problem formulation of place recognition, exploring existing challenges, and describing relations to previous surveys. Subsequently, we conduct an in-depth review of related research, which offers detailed classifications, strengths and weaknesses, and architectures. Finally, we summarize existing datasets, commonly used evaluation metrics, and comprehensive evaluation results from various methods on public datasets. This paper can serve as a valuable tutorial for newcomers entering the field of place recognition and for researchers interested in long-term robot localization. We pledge to maintain an up-to-date project on our website https://github.com/ShiPC-AI/LPR-Survey.Comment: 26 pages,13 figures, 5 table

An Artifact in Intracellular Cytokine Staining for Studying T Cell Responses and Its Alleviation.

Intracellular cytokine staining (ICS) is a widely employed ex vivo method for quantitative determination of the activation status of immune cells, most often applied to T cells. ICS test samples are commonly prepared from animal or human tissues as unpurified cell mixtures, and cell-specific cytokine signals are subsequently discriminated by gating strategies using flow cytometry. Here, we show that when ICS samples contain Ly6G+ neutrophils, neutrophils are ex vivo activated by an ICS reagent - phorbol myristate acetate (PMA) - which leads to hydrogen peroxide (H2O2) release and death of cytokine-expressing T cells. This artifact is likely to result in overinterpretation of the degree of T cell suppression, misleading immunological research related to cancer, infection, and inflammation. We accordingly devised easily implementable improvements to the ICS method and propose alternative methods for assessing or confirming cellular cytokine expression

Saliency-Enabled Coding Unit Partitioning and Quantization Control for Versatile Video Coding

The latest video coding standard, versatile video coding (VVC), has greatly improved coding efficiency over its predecessor standard high efficiency video coding (HEVC), but at the expense of sharply increased complexity. In the context of perceptual video coding (PVC), the visual saliency model that utilizes the characteristics of the human visual system to improve coding efficiency has become a reliable method due to advances in computer performance and visual algorithms. In this paper, a novel VVC optimization scheme compliant PVC framework is proposed, which consists of fast coding unit (CU) partition algorithm and quantization control algorithm. Firstly, based on the visual saliency model, we proposed a fast CU division scheme, including the redetermination of the CU division depth by calculating Scharr operator and variance, as well as the executive decision for intra sub-partitions (ISP), to reduce the coding complexity. Secondly, a quantization control algorithm is proposed by adjusting the quantization parameter based on multi-level classification of saliency values at the CU level to reduce the bitrate. In comparison with the reference model, experimental results indicate that the proposed method can reduce about 47.19% computational complexity and achieve a bitrate saving of 3.68% on average. Meanwhile, the proposed algorithm has reasonable peak signal-to-noise ratio losses and nearly the same subjective perceptual quality

Energy Efficiency Optimization for Downlink Massive MIMO With Statistical CSIT

We investigate energy efficiency (EE) optimization for single-cell massive multiple-input multiple-output (MIMO) downlink transmission with only statistical channel state information (CSI) available at the base station. We first show that beam domain transmission is favorable for energy efficiency in the massive MIMO downlink, by deriving a closed-form solution for the eigenvectors of the optimal transmit covariance matrix. With this conclusion, the EE optimization problem is reduced to a real-valued power allocation problem, which is much easier to tackle than the original large-dimensional complex matrix-valued precoding design problem. We further propose an iterative water-filling-structured beam domain power allocation algorithm with low complexity and guaranteed convergence, exploiting the techniques from sequential optimization, fractional optimization, and random matrix theory. Numerical results demonstrate the near-optimal performance of our proposed statistical CSI aided EE optimization approach.Comment: 32 pages, 6 figures. Accepted for publication in the IEEE Transactions on Wireless Communication

Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status.

The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have been reported. In this study, using mouse models of breast cancer, we demonstrate that the metastasis-modulating effects of neutrophils are dictated by the status of host natural killer (NK) cells. In NK cell-deficient mice, granulocyte colony-stimulating factor-expanded neutrophils show an inhibitory effect on the metastatic colonization of breast tumor cells in the lung. In contrast, in NK cell-competent mice, neutrophils facilitate metastatic colonization in the same tumor models. In an ex vivo neutrophil-NK cell-tumor cell tri-cell co-culture system, neutrophils are shown to potentially suppress the tumoricidal activity of NK cells, while neutrophils themselves are tumoricidal. Intriguingly, these two modulatory effects by neutrophils are both mediated by reactive oxygen species. Collectively, the absence or presence of NK cells, governs the net tumor-modulatory effects of neutrophils